Dr Carmine Maria Pariante

MD, MRCPsych, PhD

Consultant Psychiatrist | Senior Lecturer

Dr Carmine Pariante is a consultant psychiatrist in the Perinatal Service and also works in the division of psychological medicine at the Institute of Psychiatry, King’s College London. He is head of the perinatal psychiatry section and head of the stress, psychiatry and immunology section and laboratory.

Other roles

Since 2001, Dr Pariante has been involved in planning and implementing the Maudsley Forum, a course for European psychiatrists, held at the Institute. This is an annual, one-week course, with lectures and small group workshops for 50 select European psychiatrists.

Background

Dr Pariante completed a degree in medicine in 1990. Since then, he has conducted research in Italy (1990-1994), America (Emory University School of Medicine, Atlanta 1995-1997), and in the UK (Institute of Psychiatry, 1997-present).

In 1997, he passed the Membership of the Royal College of Psychiatrists examination and started a clinical training fellowship.

In 2002, he became a clinical lecturer, obtained a PhD in 2003, and became senior lecturer and MRC clinician scientist fellow in 2004. In 2007, he became a reader.

Research

Dr Pariante is particularly interested in the pathogenesis of major depression and the mechanism of action relating to antidepressant drugs. More recently, he has been extending this research stream into studying depression in pregnancy and postpartum.

He has studied the role of glucocorticoid hormones and their receptors in the pathogenesis of major depression and in the molecular mechanism of antidepressant drugs in-vitro. The main research finding is the description of the mechanism by which antidepressants increase the function of the transcription factors named ‘glucocorticoid receptor

Published

Markopoluou K, Papadopoulos AS, Juruena MF, Poon L, Pariante CM & Cleare AJ. “The ratio of cortisol/DHEA in treatment resistant depression”. Psychoneuroendocrinology, 34:19-26, 2009.

Juruena MF, Pariante CM, Papadopoulos AS, Poon L, Lightman S, & Cleare AJ. “The prednisolone suppression test in depression: a prospective study of the role of HPA axis dysfunction in treatment resistance”. British Journal of Psychiatry, in press.

Sugden K, Pariante CM, McGuffin P, Aitchison KJ, D’Souza UM. “Housekeeping gene expression is affected by antidepressant treatment in a mouse fibroblast cell line”. Journal of Psychopharmacology, in press.

Bull SJ, Huezo-Diaz P, Binder EB, Cubells JF, Ranjith G, Maddock C, Miyazaki C, Alexander N, Hotopf M, Cleare AJ, Norris S, Cassidy E, Aitchison KJ, Miller AH, and Pariante CM. “Functional Polymorphisms in the Interleukin-6 and Serotonin Transporter Genes and Depression and Fatigue Induced by Interferon-alpha and Ribavirin Treatment”. Molecular Psychiatry, in press.

Pennington K, Focking M, McManus CA, Pariante CM, Dunn MJ, Cotter D. “A proteomic investigation of similarities between conventional and herbal antidepressant treatments”. Journal of Psychopharmacology, in press.

Carvalho LA, Gorenstein C, More. R, Pariante CM and Markus R. (2008). “Effect of antidepressants on melatonin metabolite in depressed patients”. Journal of Psychopharmacology, in press .

Danese A, Moffitt T, Pariante CM, Ambler A, Poulton R, Caspi A.(2008). “Elevated inflammation levels in depressed adults with a history of childhood maltreatment”. Archives of General Psychiatry, 65:409-415.

Mason B*, Pariante CM*, Thomas SA (2008). “A revised role for p-glycoprotein in the brain distribution of dexamethasone, cortisol, and corticosterone in wild type and abcb1a/b-deficient mice”. Endocrinology, 149:5244-5253. [* joint first authors.]

Carvalho LA, Papadopoulos A, Poon L, Kerwin RW, Cleare AJ, and Pariante CM (2008). “Clomipramine in vitro reduces glucocorticoid receptor function in healthy subjects but not depressed patients”. Neuropsychopharmacology, 33:3182-3189.

Pennington K, Beasley CL ,Dicker P, Fagan A, English J, Pariante CM, Wait R, Dunn MJ, Cotter D (2008). “Prominent synaptic and metabolic abnormalities revealed by proteomic analysis of the dorsolateral prefrontal cortex in schizophrenia and bipolar disorder”. Molecular Psychiatry, 13:1102-17.

Su KP, Huang SY, Chiu TH, Huang KC, Huang CL, Chang HC, Pariante CM (2008). “Omega-3 Fatty Acids for Major Depressive Disorder During Pregnancy: Results From a Randomized, Double-Blind, Placebo-Controlled Trial”. Journal of Clinical Psychiatry, 69:644-651.

Mondelli V, Dazzan P, Gabilondo A, K Tournikioti, M Walshe, N Marshall, K Schulze, RM Murray, C McDonald*, Pariante CM* (2008). “Pituitary volume in relatives of patients with schizophrenia and bipolar disorder”. Psychoneuroendocrinology, 33:1004-1012. [* joint last authors.]

Huang SY, Yang HT, Chiu CC, Pariante CM, Su KP. (2008). “Omega-3 fatty acids on the forced-swimming test”. Journal of Psychiatric Research, 42:58-63.

P.-L. Wu, K.-F. Liao, C.-Y. Peng, C.M. Pariante, K.-P Su. Manic episode associated with citalopram therapy for interferon-induced depression in a patient with chronic hepatitis C infection. General Hospital Psychiatry, 2007, 29, 374-376.

C.-L. Huang, H.-B. Hsu, C. M. Pariante, K.P. Su. A pilot crossover study on QTc interval associated with olanzapine and risperidone. Journal of Clinical Psychiatry, 2007, 68, 803-805.

J.L.W. Yau, J. Noble, S. Thomas, R. Kerwin, P.E. Morgan, S. Lightman, J.R. Seckl, C.M. Pariante. The antidepressant desipramine requires the abcbi (MDRI)-type p-glycoprotein to upregulate the glucocorticoid receptor in mice. Neuropsychopharmacology. 2007, Epub Mar 14.

A. Danese, C.M. Pariante, A. Caspi, A. Taylor, R. Poulton. Childhood maltreatment predicts adult inflammation in a life-course study. Proceedings of the National Academy of Sciences, 2007, 104:1319-24.

V. Mondelli, L. Gianotti, A. Picu, G. Abbate Daga, R. Giordano, R. Berardelli, C.M. Pariante, S. Fassino, E. Ghigo, E. Arvat. Neuroendocrine effects of citalopram infusion in anorexia nervosa. Psychoneuroendocrinology, 2006, 31, 1139-1148.

M. Juruena, A. Cleare, A.S. Papadopoulos, L. Poon, S. Lightman. C.M. Pariante. Different response to dexamethasone and prednisolone in the same depressed patients. Psychopharmacology (Berl), 2006,189, 225-235.

C.-Y. Lin, P.-L. Wu, C.M. Pariante, K.-P. Su. A cross-over study of prolactin changes associated with risperidone and olanzapine. Journal of Clinical Psychiatry, 2006, 67, 1470.

S.Y. Huang, H.-T. Yang, C.-C. Chiu, C.M. Pariante, K.-P. Su. Omega-3 fatty acids on the forced-swimming test. Journal of Psychiatric Research, 2006, Epub Oct 30.

K.-P. Su, P.-L. Wu, C.M. Pariante. A cross-over study on of lipid and weight changes associated with olanzapine and risperidone. Psychopharmacology (Berl) 2005, 183(3):383-6.

M.G. Orru, A. Baita, R. Sitzia, A. Costa, E. Muntoni, S. Landau, L. Chessa, M.G. Farci, B. Carpiniello, C.M. Pariante. Interferon-alpha-induced psychiatric side effects in patients with chronic viral hepatitis: a prospective, observational, controlled study [Article in Italian]. Epidemiologia & Psichiatria Sociale 2005, 14:145-53.

C.M. Pariante, P. Dazzan, A. Danese, K.D. Morrgan, F. Brudaglio, C. Morgan, P. Fearon, K. Orr, G. Hutchinson, C. Pantelis, D. Velakoulis, P.B. Jones, J. Leff, R.M. Murray. Increased pituitary volume in antipsychotic- free and antipsychotic-treated patients of the æsop first-onset psychosis study. Neuropsychopharmacology, 2005, 30:1923-31.

B. Garner, C.M. Pariante, S.J. Wood, D. Velakoulis, L. Phillips, B. Soulsby, W.J. Brewer, D.J. Smith, P. Dazzan, G.E. Berger, A.R. Yung, M. van den Buuse, R. Murray, P.D. McGorry, C. Pantelis. Pituitary volume predicts future transition to psychosis in individuals at ultra-high risk of developing psychosis. Biological Psychiatry, 2005, 58:417-23.

C. Maddock, S. Landau, K. Barry, P. Maulayah, M. Hotopf , A. Cleare, S. Norris, C.M. Pariante. Psychopathological symptoms during interferon-? and ribavirin treatment: effects on virologic response. Molecular Psychiatry, 2005, 10:332-333.

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