Dr Oliver Howes, Consultant Psychiatrist

BM BCh, MA, MRCPsych, PhD, DM

oliver howe pictureConsultant Psychiatrist

Oliver Howes is Group Head/ Reader at the Institute of Psychiatry, London, and the MRC CSC Psychiatric Imaging Group, Imperial College, Hammersmith Hospital. His clinical work is as Consultant Psychiatrist at The Maudsley Hospital where, amongst other things, he runs a service for refractory psychoses.

 

His research interests centre on the causes and treatment of psychosis. His recent work has focussed on characterising the dopaminergic system in the psychotic prodrome, the effects of antipsychotic drugs on the endocrine system, & the causes of cognitive impairment in schizophrenia. This work has been recognised through a number of awards including the Schizophrenia International Research Society Rising Star Award 2013, European Psychiatric Association Biological Psychiatry Prize (2012), the Royal Society of Medicine Psychiatry Prize (2010), Royal College of Psychiatrists research prize (2005), the British Association of Psychopharmacology Clinical Psychopharmacology Prize (2007) and awards at the International Conference of Schizophrenia Research (2006), the European College of Neuropsychopharmacology (2008). He was made an honorary associate of the European College of Neuropsychopharmacology in 2006.

 

Other career highlights include a stint as junior potato scrubber on a farm.

Publications

Books:

Bhugra D, Howes OD.(eds). Handbook for Psychiatric Trainees. Gaskell Publications, 2008.

Bhugra D, Bell S, Burns D, Howes OD (eds). The Complete Psychiatrist (a guide for professional practice in psychiatry). RCPsych Publications, 2010.

Book chapters:

Howes OD, Murray RM. The neurochemical basis of schizophrenia. In: The Oxford Companion to the Mind (2nd Edition), Ed: R Gregory. Oxford University Press, 2004.

Howes OD. General Psychiatry. In: Oxford Handbook of Tropical Medicine (2nd Edition), Eddlestone M, Pierini S. Oxford University Press, 2004.

Howes OD, Murray RM. Schizophrenia. In: The Oxford Companion to the Mind (2nd Edition), Ed: R Gregory. Oxford University Press, 2004.

Howes OD, Kapur S. Functional imaging with ligands in schizophrenia: therapeutic inferences. In: Therapeutic strategies in schizophrenia. Clinical Publishing, 2010.

Howes OD. Dopamine: psychotic fire-starter? In: The neurobiology of the prodrome to psychosis. Eds: McGuire, Fusar-Poli & Borwardt. Maudsley Monograph.

Howes OD. Midbrain dopaminergic function and schizophrenia. In: Schizophrenia: The Final Frontier (Festschrift for Robin Murray). Maudsley Monograph.

Murray RM, Di Forti M, Howes OD. How does stress lead to psychosis? In: Search for the cause of schizophrenia. Sao Paolo, 2010.

Howes OD. Schizophrenia. In: Neuromethods: Molecular Imaging in the Neurosciences (Ed: G Grunder), Oxford University Press. In Prep.

Journal publications:

Howes OD, Salkovskis PM. Health anxiety in medical students (a cross-sectional study). Lancet 1998; 351: 1332.

Howes O. Environmentally friendly health care begins in Madagascar. Lancet 1998; 351: 577.

Howes O. Hypochondriasis: an overview with reference to medical students. Student British Medical Journal 1999; 8: 56-60.

Howes OD, McKenzie KJ. Manic psychosis induced by chronic alpha interferon treatment for hepatitis C. International Journal of Psychiatry in Clinical Practice. 2000; 4(2): 161-162.

Howes O. Smith S. Hyperprolactinaemia caused by antipsychotic drugs. Endocrine antipsychotic side effects must be systemically assessed. British Medical Journal. 2002; 324: 1278-9, May 25.

Howes O, Smith S. The effect of antipsychotics on bone mineral density. Schizophrenia Research. 2003; 60 (1): 357.

Howes O. Sex, psychosis and osteoporosis: antipsychotics and prolactin. Irish Psychiatrist. 2003; 4 (2); 43-46.

Howes O, Ohlsen R, Pilowsky LS. Effect of clozapine on mortality. British Journal of Psychiatry. 2003: 183; 460.

Gaughran F, Chrisman L, Howes OD, Vincent A. Serum Glutamic Acid Decarboxylase 65 Antibody Levels in People with Schizophrenia and their families. Schizophrenia Research 2004; Sept: 1-3.

Howes OD, Rifkin L. DKA coma following olanzapine initiation in a previously euglycaemic woman and successful continued therapy with olanzapine. Journal of Pychopharmacology 2004; 18: 435-37.

Howes OD, Smith S, Aitchison KJ. Comment on Hyperprolactinaemia and antipsychotic therapy in schizophrenia. Current Medical Research and Opinion. 2004 Oct; 20: 1649.

Meaney AM, Smith S, Howes OD, O’Brien M, Murray RM, O’Keane V. Effects of long-term prolactin-raising antipsychotic medication on bone mineral density in patients with schizophrenia. British Journal of Psychiatry. 2004: 184; 503-508.

Howes OD, Smith S. Bone mineral density and prolactin associations in patients with chronic schizophrenia. Schizophrenia Research. 2004: 66 (1); 77-78.

Howes OD, Salkovskis PM. Health anxiety in medical students (a cross-sectional study). Lancet 1998; 351: 1332.

Howes O. Environmentally friendly health care begins in Madagascar. Lancet 1998; 351: 577.

Howes O. Hypochondriasis: an overview with reference to medical students. Student British Medical Journal 1999; 8: 56-60.

Howes OD, McKenzie KJ. Manic psychosis induced by chronic alpha interferon treatment for hepatitis C. International Journal of Psychiatry in Clinical Practice. 2000; 4(2): 161-162.

Howes O. Smith S. Hyperprolactinaemia caused by antipsychotic drugs. Endocrine antipsychotic side effects must be systemically assessed. British Medical Journal. 2002; 324: 1278-9, May 25.

Howes O, Smith S. The effect of antipsychotics on bone mineral density. Schizophrenia Research. 2003; 60 (1): 357.

Howes O. Sex, psychosis and osteoporosis: antipsychotics and prolactin. Irish Psychiatrist. 2003; 4 (2); 43-46.

Howes O, Ohlsen R, Pilowsky LS. Effect of clozapine on mortality. British Journal of Psychiatry. 2003: 183; 460.

Gaughran F, Chrisman L, Howes OD, Vincent A. Serum Glutamic Acid Decarboxylase 65 Antibody Levels in People with Schizophrenia and their families. Schizophrenia Research 2004; Sept: 1-3.

Howes OD, Rifkin L. DKA coma following olanzapine initiation in a previously euglycaemic woman and successful continued therapy with olanzapine. Journal of Pychopharmacology 2004; 18: 435-37.

Howes OD, Smith S, Aitchison KJ. Comment on Hyperprolactinaemia and antipsychotic therapy in schizophrenia. Current Medical Research and Opinion. 2004 Oct; 20: 1649.

Meaney AM, Smith S, Howes OD, O’Brien M, Murray RM, O’Keane V. Effects of long-term prolactin-raising antipsychotic medication on bone mineral density in patients with schizophrenia. British Journal of Psychiatry. 2004: 184; 503-508.

Howes OD, Smith S. Bone mineral density and prolactin associations in patients with chronic schizophrenia. Schizophrenia Research. 2004: 66 (1); 77-78.

Howes OD, Smith S. Alendronic Acid for antipsychotic-related osteopenia. American Journal of Psychiatry 2004; 161: 756.

Howes OD, McDonald CM, Cannon M, Arsenault L, Boydell J, Murray RM. Pathways to schizophrenia: the impact of environmental factors. International Journal of Neuropsychopharmacology. 2004: 7 (S1); 7-13.

Howes OD, Gaughran FP, Amiel SA, Murray RM, Pilowsky LS. The Effect of Clozapine on Factors Controlling Glucose Homeostasis J Clin Psychiatry 2004; 65 (10):1352-1355.

Howes OD, Bhatnagar A, Gaughran FP, Amiel SA, Murray RM, Pilowsky LS. A prospective study of impairment in glucose control caused by clozapine without changes in insulin resistance. American Journal of Psychiatry. 2004: 161 (2); 361-363.

Howes OD, Amiel SA, Pilowksy LS. The effect of antipsychotic drugs on glucose control and diabetes mellitus. Adv Schizophr Clin Psychiatry. 2005;1(4): 1-15.

Howes OD, Aitchison KJ, Smith S. Prolactin levels and erectil function in patients treated with risperidone. J Clin Psychopharmacology. 2005; 25(4):393-4.

Howes OD, Wheeler MJ, Meaney AM, O’Keane V, Fogelman I, Blake G, Murray RM, Smith S. Bone mineral density and its relationship to prolactin levels in patients taking antipsychotic treatment. J Clin Psychpharmacology. 2005; 25(3): 259-61.

Howes OD. Compulsions in depression. American Journal of Psychiatry. 2006; 163(9): 1642.

Howes OD. Review of Evidence-based psychopharmacology. J Psychopharmacol. 2006 Nov 8.

Howes OD, Gaughran F, Pilowsky LS, Murray RM, Smith S. The relationship between prolactin levels and glucose homeostasis in antipsychotic-treated schizophrenic patients. J Clin Psychopharmacol. 2006 Dec;26(6):629-31.

Howes OD, Wheeler MJ, Pilowsky LS, Murray RM, Smith S. Sexual function and gonadal hormones in patients taking antipsychotic treatment for schizophrenia or schizoaffective disorder. Journal of Clinical Psychiatry 2007 Mar;68(3):361-7.

Howes OD, Smith S, Amiel SA, Gaughran FP. Metabolic and endocrine disease in patients taking antipsychotic medication. B J Psych on-line (10 August 2007)

Howes OD, Montgomery AJ, Asselin MC, Murray RM, Grasby PM, McGuire PK. Molecular imaging studies of the striatal dopaminergic system in psychosis and predictions for the prodromal phase of psychosis. Br J Psychiatry 2007 Dec;51:s13-8.

Howes OD, Weinstein S, Tabraham P, Valmaggia L, Broome M, McGuire P. Street slang and schizophrenia. Britich Medical Journal. 2007 Dec 22;335(7633):1294.

McGuire P, Howes OD, Stone J, Fusar-Poli P. Functional neuroimaging in schizophrenia: diagnosis and drug discovery. Trends Pharmacol Sci. 2008 29(2): 91-98.

Fusar-Poli P, Howes O, Valmaggia L, McGuire P. Truman signs and vulnerability to psychosis. Br J Psychiatry. 2008;193(2):168

Bramon E, Shaikh M, Broome M, Lappin J, Bergé D, Day F, Woolley J, Tabraham P, Madre M, Johns L, Howes O, Valmaggia L, Pérez V, Sham P, Murray RM, McGuire P. Abnormal P300 in people with high risk of developing psychosis. Neuroimage. 2008;41(2):553-60.

Howes OD, McGuire PK, Kapur S. Understanding pathophysiology is crucial in linking clinical staging to targeted therapeutics in schizophrenia. World Psychiatry. 2008 Oct;7(3):162-3.

Fusar-Poli P, Howes O, Valli I, Allen P, Broome M, Grasby P, McGuire P. Multimodal functional imaging investigation before and after the onset of psychosis. Int J Neuropsychopharmacol. 2008 Oct 17:1-3.

Bose SK, Turkheimer FE, Howes OD, Mehta MA, Cunliffe R, Stokes PR, Grasby PM. Classification of schizophrenic patients and healthy controls using [18F] fluorodopa PET imaging. Schizophr Res. 2008 Oct 10. 2008

Elevated striatal dopamine function linked to prodromal signs of schizophrenia. Howes OD, Montgomery AJ, Asselin MC, Murray RM, Valli I, Tabraham P, Bramon-Bosch E, Valmaggia L, Johns L, Broome M, McGuire PK, Grasby PM. Arch Gen Psychiatry. 2009 Jan;66(1):13-20.

Opposite effects of catechol-O-methyltransferase Val158Met on cortical function in healthy subjects and patients with schizophrenia. Prata DP, Mechelli A, Fu CH, Picchioni M, Kane F, Kalidindi S, McDonald C, Howes O, Kravariti E, Demjaha A, Toulopoulou T, Diforti M, Murray RM, Collier DA, McGuire PK. Biol Psychiatry. 2009 Mar 15;65(6):473-80

Sex hormone augmentation as an adjunctive treatment in schizophrenia. Howes OD, Hundal H. J Clin Psychopharmacol. 2009 Apr;29(2):195-6.

Julius Wagner-Jauregg, 1857-1940. Howes OD, Khambhaita A, Fusar-Poli P. Am J Psychiatry. 2009 Apr;166(4):409.

Functionally defined regions may aid interpretation of striatal dopamine elevation in schizophrenia. Egerton A, McGuire PK, Howes OD. Schizophr Res. 2009 Apr;109(1-3).

The dopamine hypothesis of schizophrenia: version III–the final common pathway. Howes OD, Kapur S. Schizophr Bull. 2009 May;35(3):549-62.

The dopaminergic basis of human behaviors: A review of molecular imaging studies. Egerton A, Mehta MA, Montgomery AJ, Lappin JM, Howes OD, Reeves SJ, Cunningham VJ, Grasby PM. Neurosci Biobehav Rev. 2009 Jul;33(7):1109-32.

The effect of ageing on grey and white matter reductions in schizophrenia. Bose SK, Mackinnon T, Mehta MA, Turkheimer FE, Howes OD, Selvaraj S, Kempton MJ, Grasby PM. Schizophr Res. 2009 Jul;112(1-3):7-13.

Pseudohallucinations versus true hallucinations in prodromal psychosis: does it really matter? Fusar-Poli P, Howes OD, McGuire P. J Clin Psychiatry. 2009 Jul;70(7):1056-7

Mechanisms underlying psychosis and antipsychotic treatment response in schizophrenia: insights from PET and SPECT imaging. Howes OD, Egerton A, Allan V, McGuire P, Stokes P, Kapur S. Curr Pharm Des. 2009;15(22):2550-9.

Acute effect of the anti-addiction drug bupropion on extracellular dopamine concentrations in the human striatum: An [(11)C]raclopride PET study. Egerton A, Shotbolt JP, Stokes PR, Hirani E, Ahmad R, Lappin JM, Reeves SJ, Mehta MA, Howes OD, Grasby PM. Neuroimage. 2010 Mar;50(1):260-6 PMID: 19969097

Further evaluation of the carbon11-labeled D(2/3) agonist PET radiotracer PHNO: Reproducibility in tracer characteristics and characterization of extrastriatal binding. Egerton A, Hirani E, Ahmad R, Turton DR, Brickute D, Rosso L, Howes OD, Luthra SK, Grasby PM. Synapse. 2009 Dec 2;64(4):301-312.

Impaired verbal self-monitoring in individuals at high risk of psychosis. Johns LC, Allen P, Valli I, Winton-Brown T, Broome M, Woolley J, Tabraham P, Day F, Howes O, Wykes T, McGuire P. Psychol Med. 2009 Dec 2:1-10.

Glutamate dysfunction in people with prodromal symptoms of psychosis: relationship to gray matter volume. Stone JM, Day F, Tsagaraki H, Valli I, McLean MA, Lythgoe DJ, O’Gorman RL, Barker GJ, Howes OD, (OASIS), McGuire PK. Biol Psychiatry. 2009 Sep 15;66(6):533-9.

Johann Cristian Reil on the 200th anniversary of the first description of the insula (1809). Fusar-Poli P, Howes O, Borgwardt S. J Neurol Neurosurg Psychiatry. 2009 Dec;80(12):1409.

Mind the translation gap: problems in the implementation of early intervention services. Howes OD, Lim SJ, Fusar-Poli P. Psychol Med. 2010 Jan;40(1):171-2.

The assessment of post-graduate psychiatric competence: recent developments and their implications. Howes OD. Higher Education Research Network Journal, 2010; 1; 59-67.

Abnormal frontostriatal interactions in people with prodromal signs of psychosis: a multimodal imaging study. Fusar-Poli P, Howes OD, Allen P, Broome M, Valli I, Asselin MC, Grasby PM, McGuire PK. Arch Gen Psychiatry. 2010 Jul;67(7):683-91.

Altered Relationship Between Hippocampal Glutamate Levels and Striatal Dopamine Function in Subjects at Ultra High Risk of Psychosis. Howes OD*, Stone JM*, Egerton A, Kambeitz J, Allen P, Lythgoe DJ, O’Gorman RL, McLean MA, Barker GJ, McGuire P. Biol Psychiatry. 2011; 68(7):599-602.

A comprehensive review and model of putative prodromal features of bipolar affective disorder. Howes OD, Lim S, Theologos G, Yung AR, Goodwin GM, McGuire P. Psychol Med. 2010 Sep 14:1-11.

Delusional ideation, manic symptomatology and working memory in a cohort at clinical high-risk for psychosis: A longitudinal study. Broome MR, Day F, Valli I, Valmaggia L, Johns LC, Howes O, Garety P, McGuire PK. Eur Psychiatry. 2010 Oct 8.PMID: 20934858

Decreased regional gray matter volume in S’ allele carriers of the 5-HTTLPR triallelic polymorphism. Selvaraj S, Godlewska BR, Norbury R, Bose S, Turkheimer F, Stokes P, Rhodes R, Howes O, Cowen PJ. Mol Psychiatry. 2010 Nov 2.PMID: 21042318

Characterization of the Anterior Cingulate’s Role in the At-Risk Mental State using Graph Theory. Lord LD, Allen P, Expert P, Howes O, Lambiotte R, McGuire P, Bose SK, Hyde S, Turkheimer FE. Neuroimage. 2011 Feb 10. PMID: 21316462

Abnormal prefrontal activation directly related to pre-synaptic striatal dopamine dysfunction in people at clinical high risk for psychosis. Fusar-Poli P, Howes OD, Allen P, Broome M, Valli I, Asselin MC, Montgomery AJ, Grasby PM, McGuire P. Mol Psychiatry. 2011 Jan;16(1):67-75.

Progressive increase in striatal dopamine synthesis capacity as patients develop psychosis: a PET study. Howes O, Bose S, Turkheimer F, Valli I, Egerton A, Stahl D, Valmaggia L, Allen P, Murray R, McGuire P. Mol Psychiatry. 2011 Mar 1 PMID: 21358709

Papers under review:

Fusar-Poli P, Howes OD. McGuire PH. A study of the features of an at risk mental state that are predictive of transition to psychosis. British Journal of Psychiatry.

Papers in preparation:

Roiser J, Howes OD, Day F, Chaddock C, Egerton A, McGuire PK, Grasby PG. A PET and fMRI study of salience in the prodrome of schizophrenia.

Asselin MC, Howes OD, Nahmias C, Osman S, Grasby PG. Sensitivity of graphically derived constants of FDOPA to plasma concentration of the brain crossing metabolite 3-OMFD.

Tabraham P, Brett C, Johns L, Valmaggia L, Broome M, Woolley J, Bramon E, Howes O, McGuire P. Spatial working memory is impaired in individuals at high risk of psychosis.

Lucia R. Valmaggia, Majella Byrne, Fern Day, Paolo Fusar-Poli, Matthew R Broome, Louise Johns, Oliver Howes, Paddy Power, Philip K McGuire. Transition to psychosis in individuals with an at risk mental state. Does intervening early make a difference?

Selected abstracts:

Meaney, A., Smith, S., O’Brien, M., Howes, O., Murray, R., and O’Keane, V. The effect of anti-psychotic medication on bone mineral density in male and postmenopausal female patients with schizophrenia. J Psychopharmacology 15(3), 43. 2001.

Howes O, Simpson L, Meaney A, O’Keane V, Murray R, Smith S. Are prolactin raising antipsychotics associated with osteoporosis? J Psychopharmacology. 16(3), 40. A53. 2002.

Howes, O., Simpson, L., Meaney, A., O’Keane, V, Murray, R., and Smith, S. Are prolactin raising antipsychotics associated with osteoporosis? J Psychopharmacology 16(3), 23. 2002.

Meaney, A., Howes, O., Smith, S., and O’Keane, V. The effect of long-term anti-psychotic treatment on bone mineral density in patients with schizophrenia. Schizophr.Res. 53(3). 2002.

Howes OD, Fiona P Gaughran, Stephanie Amiel, Robin M Murray, Lyn S Pilowsky. The effect of clozapine on glucose homeostasis. J Psychopharmacology. 18 (3); A57. 2004.

Howes OD, Bhatnagar A, Gaughran F, Murray R, Amiel S, Pilowksy L. The effect of clozapine on factors controlling glucose homeostasis. Schizophrenia Research. 2004: 67/1S; 186.

Asselin MC, Nahmias C, Howes OD. Sensitivity of graphically derived constants of FDOPA to plasma concentration of the brain crossing metabolite 3-OMFD. Society of Nuclear Medicine 2005.

Howes, O. D., Montgomery, A. J., Asselin, M.-C., Murray, R. M., McGuire, P. K. & Grasby, P. M. The pre-synaptic dopaminergic system in subjects with at risk mental states: initial results from an on-going [18F]-DOPA PET study. J. Psychopharmacol. 20(S), A20.

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